Motif ID: FOX{F1,F2,J1}.p2

Z-value: 1.458


Transcription factors associated with FOX{F1,F2,J1}.p2:

Gene SymbolEntrez IDGene Name
FOXF1 2294 forkhead box F1
FOXF2 2295 forkhead box F2
FOXJ1 2302 forkhead box J1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXF1chr16_+_85101734-0.476.6e-02Click!
FOXF2chr6_+_1335067-0.243.7e-01Click!
FOXJ1chr17_-_71648965-0.126.6e-01Click!


Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_30121741 2.778 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr1_-_159459814 2.583 APOA2
apolipoprotein A-II
chr11_-_117589283 2.554 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr2_-_32344192 2.461 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr17_+_69939130 2.459 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_20562962 2.431 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr1_+_116455898 2.374 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr1_-_47468029 2.362 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_-_159459999 2.346 NM_001643
APOA2
apolipoprotein A-II
chr12_-_51629874 2.272 KRT8
keratin 8
chr9_+_135276940 2.243 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr2_+_161980865 2.239 NM_006593
TBR1
T-box, brain, 1
chr1_-_57204208 2.229 NM_000066
C8B
complement component 8, beta polypeptide
chr22_+_19458378 2.144 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_-_138862273 2.123


chr15_-_38387410 2.112 NM_004573
PLCB2
phospholipase C, beta 2
chr2_-_165133239 2.112 GRB14
growth factor receptor-bound protein 14
chr12_-_101835026 2.084 PAH
phenylalanine hydroxylase
chr6_-_138862271 2.070 NM_001144060
NHSL1
NHS-like 1
chr7_+_50318801 2.054 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr6_+_112481970 2.042 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr12_-_94914133 2.029 NM_002108
HAL
histidine ammonia-lyase
chr20_-_45410033 2.001 ZMYND8
zinc finger, MYND-type containing 8
chr8_-_110724594 1.977 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr14_+_31868229 1.927 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr4_+_100714995 1.921 MTTP
microsomal triglyceride transfer protein
chr1_-_205161821 1.901 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr6_-_41823056 1.889 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr1_-_205272619 1.885 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr9_+_135277264 1.877 ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr9_-_205892 1.857 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr13_+_49658016 1.848


chr13_-_45654292 1.832 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_38052481 1.828 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr15_-_38387357 1.818 PLCB2
phospholipase C, beta 2
chr12_+_27740694 1.805 NM_001029874
REP15
RAB15 effector protein
chr13_-_45654327 1.798 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_-_11282595 1.758 NM_002761
PRM1
protamine 1
chr12_+_77963563 1.749 NM_001135806
SYT1
synaptotagmin I
chr17_-_7023283 1.715 ASGR1
asialoglycoprotein receptor 1
chr19_+_17723285 1.708 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr13_-_45654296 1.699 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_169637255 1.687 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_+_147754467 1.669 FBXO38
F-box protein 38
chr2_-_233586145 1.640 NGEF
neuronal guanine nucleotide exchange factor
chr2_-_233586164 1.568 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr5_+_137701122 1.567 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr10_+_102722275 1.559 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_+_9686572 1.558 GLP2R
glucagon-like peptide 2 receptor
chr20_-_22514092 1.553 NM_153675
FOXA2
forkhead box A2
chr15_-_38387317 1.503 PLCB2
phospholipase C, beta 2
chr7_+_106292975 1.495 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr17_-_43390108 1.447 NM_024320
PRR15L
proline rich 15-like
chr16_-_66590856 1.440 NM_022355
DPEP2
dipeptidase 2
chr5_+_171553780 1.440 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr4_-_123761615 1.420 NM_021803
IL21
interleukin 21
chr19_-_53081326 1.402 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr22_-_35835548 1.402 TMPRSS6
transmembrane protease, serine 6
chr2_-_43919392 1.401 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr7_-_25234582 1.383 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_40635058 1.356 NM_001198980
SMAP2
small ArfGAP2
chr6_-_26038817 1.351 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr1_+_28134090 1.349 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr2_-_135498716 1.346 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr17_+_70244945 1.345 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr8_+_55691179 1.337 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr12_+_119900677 1.314 HNF1A
HNF1 homeobox A
chr15_-_38387164 1.311 PLCB2
phospholipase C, beta 2
chr12_-_69837831 1.308 TSPAN8
tetraspanin 8
chr11_-_34491878 1.295 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr11_+_59858870 1.279 NM_139249
MS4A6E
membrane-spanning 4-domains, subfamily A, member 6E
chr1_-_167822248 1.262 F5
coagulation factor V (proaccelerin, labile factor)
chr15_-_38387266 1.256 PLCB2
phospholipase C, beta 2
chr7_+_116151411 1.254 MET
met proto-oncogene (hepatocyte growth factor receptor)
chr18_+_59726183 1.243 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr6_+_44352443 1.216 TMEM151B
transmembrane protein 151B
chr12_+_9033403 1.199 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr6_+_30238961 1.177 NM_033229
TRIM15
tripartite motif containing 15
chr2_+_143351695 1.173 KYNU
kynureninase
chr4_+_74488835 1.163 NM_000477
ALB
albumin
chr1_-_6343306 1.159 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr12_+_119900931 1.158 NM_000545
HNF1A
HNF1 homeobox A
chrX_-_153698930 1.140 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr9_-_14712669 1.137 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr5_-_169657360 1.137 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_-_21084077 1.133 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_88973144 1.118 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr1_-_1346465 1.114 NM_001145210
LOC441869
hypothetical protein LOC441869
chr6_-_25834733 1.105 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr4_+_74488910 1.103 ALB
albumin
chr5_-_142763418 1.076 NM_000176
NM_001020825
NM_001024094
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr4_-_176971175 1.046 NM_201591
GPM6A
glycoprotein M6A
chr1_-_167822334 1.037 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr2_+_86800940 1.037 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr10_-_52315390 1.035 A1CF
APOBEC1 complementation factor
chr5_-_169657312 1.023 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_+_64403668 1.015 PHF3
PHD finger protein 3
chr1_+_149877955 1.013 SNX27
sorting nexin family member 27
chr3_-_10522267 1.008 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr5_-_169657395 1.006 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_+_106293112 1.005 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr6_+_64289585 1.002 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_4781330 1.000 NM_001143970
CDYL
chromodomain protein, Y-like
chr14_+_104338423 0.998 ZBTB42
zinc finger and BTB domain containing 42
chr6_-_168222645 0.995 NM_024919
FRMD1
FERM domain containing 1
chr17_-_7023378 0.994 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chrX_-_15198093 0.984 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr2_-_39310176 0.983 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr5_-_142763393 0.980 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr20_-_52120421 0.978 BCAS1
breast carcinoma amplified sequence 1
chr1_+_196874867 0.972 PTPRC
protein tyrosine phosphatase, receptor type, C
chr5_-_169657192 0.969 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_-_106282128 0.967 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_57329834 0.965 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr19_+_15612706 0.964 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr7_-_142369519 0.960 KEL
Kell blood group, metallo-endopeptidase
chr5_-_142763481 0.959 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr10_-_50066386 0.950 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr1_+_246682699 0.945 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr4_+_69716298 0.943 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_-_23721485 0.942 NM_000638
VTN
vitronectin
chr2_+_143351536 0.937 NM_001032998
NM_003937
KYNU

kynureninase

chr16_-_87877197 0.929 ANKRD11
ankyrin repeat domain 11
chr6_-_88095714 0.919 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr7_+_77307382 0.918 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr5_-_142763252 0.916 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr8_-_131097828 0.903 FAM49B
family with sequence similarity 49, member B
chr20_-_1257809 0.891 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr3_-_10522340 0.880 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr20_-_1257782 0.877 SDCBP2
syndecan binding protein (syntenin) 2
chr22_+_36928011 0.869 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chrX_+_115215985 0.866 NM_000686
AGTR2
angiotensin II receptor, type 2
chr17_-_23721468 0.858 VTN
vitronectin
chr4_+_155703581 0.856 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_+_43919606 0.853 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr16_+_82540172 0.837 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr19_+_12995782 0.831 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_61379200 0.829 NM_001145546
NM_033106
GALP

galanin-like peptide

chr3_-_184756101 0.823 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr13_-_98708549 0.817 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr4_+_39084867 0.816 NM_175737
KLB
klotho beta
chr6_+_108988761 0.815 NM_001455
FOXO3
forkhead box O3
chr17_-_5078773 0.813 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr16_+_2749934 0.812


chr14_+_104337923 0.808 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr17_+_21946563 0.806 NM_001190452
MTRNR2L1
MT-RNR2-like 1
chr4_+_17125885 0.805 NM_001079827
CLRN2
clarin 2
chr6_-_2696152 0.802 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr19_-_63556632 0.799 NM_130786
A1BG
alpha-1-B glycoprotein
chr3_+_110024234 0.797 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr10_-_52315436 0.790 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr4_+_100957003 0.788 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr20_-_52120710 0.780 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr6_+_108988797 0.778 FOXO3
forkhead box O3
chr2_+_178893216 0.776 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr6_-_50025115 0.772 NM_001166478
DEFB133
defensin, beta 133
chr20_+_31334601 0.768 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr19_+_54621499 0.763 NM_001195256
LOC645971
hypothetical protein LOC645971
chr15_-_32398220 0.763 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr19_-_12802206 0.754 NM_001080997
RTBDN
retbindin
chr3_-_127138571 0.752 NM_001015050
NM_001195223
ALG1L

asparagine-linked glycosylation 1-like

chr8_-_131097856 0.750 FAM49B
family with sequence similarity 49, member B
chr14_+_94148466 0.748 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr17_+_69950782 0.747 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_-_23721430 0.742 VTN
vitronectin
chr4_-_155731288 0.730 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr17_+_3324096 0.729 NM_001128085
ASPA
aspartoacylase
chr7_-_126670804 0.728 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr1_-_246869181 0.723 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr1_+_32512298 0.722 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr6_+_32230172 0.715 PPT2
palmitoyl-protein thioesterase 2
chr12_-_69838045 0.715 NM_004616
TSPAN8
tetraspanin 8
chr3_+_157874898 0.714 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_+_74473672 0.710 NM_015978
TNNI3K
TNNI3 interacting kinase
chr1_+_204484081 0.709 NM_001910
NM_148964
CTSE

cathepsin E

chr1_-_28376041 0.707 NM_000952
PTAFR
platelet-activating factor receptor
chr11_-_55942283 0.700 NM_001004744
OR5R1
olfactory receptor, family 5, subfamily R, member 1
chr7_+_106292932 0.700 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr21_-_30836051 0.700 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr6_+_167445284 0.698 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr17_+_70244553 0.696 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr12_-_9804682 0.695 NM_001781
CD69
CD69 molecule
chr14_+_20226762 0.694 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr6_+_32003180 0.691 NM_000063
NM_001145903
C2

complement component 2

chr14_-_22358752 0.691 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr17_-_23721420 0.684 VTN
vitronectin
chr2_+_38009405 0.683 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr5_-_1050408 0.683 LOC100506688
hypothetical protein LOC100506688
chr15_-_77994652 0.680 NM_001100879
ST20
suppressor of tumorigenicity 20
chr1_-_155834357 0.677 NM_031282
FCRL4
Fc receptor-like 4
chr2_+_88966170 0.669


chr14_-_69333624 0.666 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr7_-_142369534 0.665 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr20_+_16676997 0.663 NM_020157
OTOR
otoraplin
chr17_-_23721351 0.663 VTN
vitronectin
chr17_-_72151314 0.660 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chrX_-_15242589 0.660 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr4_+_39084936 0.656 KLB
klotho beta
chr2_+_149119029 0.656 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr16_+_30391460 0.655 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.06 3.31e-04 GO:0007606 sensory perception of chemical stimulus
2.10 5.82e-04 GO:0007608 sensory perception of smell
1.20 5.74e-03 GO:0050896 response to stimulus
3.13 1.76e-02 GO:0007586 digestion
4.87 1.79e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
6.52 2.73e-02 GO:0050853 B cell receptor signaling pathway
2.60 3.50e-02 GO:0002252 immune effector process
4.99 3.59e-02 GO:0006958 complement activation, classical pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 4.00e-06 GO:0005886 plasma membrane
1.30 1.31e-05 GO:0071944 cell periphery
1.41 3.94e-04 GO:0005576 extracellular region
1.65 2.65e-03 GO:0005615 extracellular space
1.52 8.06e-03 GO:0044421 extracellular region part
1.14 2.62e-02 GO:0016020 membrane
3.57 3.22e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.83 5.73e-06 GO:0004930 G-protein coupled receptor activity
1.58 1.24e-04 GO:0004888 transmembrane receptor activity
1.48 2.20e-04 GO:0004872 receptor activity
1.42 3.54e-04 GO:0004871 signal transducer activity
1.42 3.54e-04 GO:0060089 molecular transducer activity
2.08 4.46e-04 GO:0004984 olfactory receptor activity
3.17 6.39e-03 GO:0004867 serine-type endopeptidase inhibitor activity